[CusaBio] Recombinant Porphyromonas gingivalis Gingipain R2(rgpB), partial

Pre-order: ETA 6-8 weeks
Storage: -20 degree celcius

Porphyromonas gingivalis Gingipain R2/rgpB (CSB-EP310587EYA) with an N-terminal 6xHis-SUMO-tag is a partial-length recombinant protein generated in E.coli. The expressed region encodes the AA Tyr230-Cys473 of Porphyromonas gingivalis. This recombinant rgpB protein was evaluated by the LC-MS/MS analysis. The purity of this protein is up to 90% through SDS-PAGE analysis. This protein may be used to produce specific antibodies or in the studies of microbiology.

Arginine-specific gingipain 2 (rgpB) is an arginine-specific extra-cellular protease expressed on the surface of the oral pathogen Porphyromonas gingivalis outer membrane. It is one of the major viral virulence factors. Endogenous peptidylarginine deiminase enzyme (P.PAD), a virulence factor capable of citrullinating human and bacterial proteins, including auto-citrullination, interacts with rgpB. RgpB is essential for P. gingivalis to citrullinate peptides. Only after degradation by rgpB can P.PAD convert peptidylarginine into peptidylcitrulline.